InterSystems IRIS Alternatives (January 2026)

InterSystems IRIS is a database management system (DBMS) that makes it easier to build machine learning-enabled applications that connect data and application silos.

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1.
InterSystems IRIS for Health Data Management| InterSystems
https://www.intersystem
.com/products/intersystems-iris-for-health/

FHIR-based Healthcare Application Development. Advanced Interoperability. Unprecedented Speed. Massive Scale.

3.
IBM Informix
https://www.ib
.com/products/informix/

IBM Informix is an embeddable, high-performance database for integrating SQL, NoSQL, JSON, time-series and spatial data. It is available as a managed service on IBM Cloud, as standalone software, and within IBM Cloud Pak for Data.

4.
SingleStore | The Real-Time Data Platform for Intelligent Applications
https://www.singlestor
.com/

Designed for applications, analytics and AI, SingleStore is the world's only real-time data platform to read, write and reason on petabyte-scale data in a few milliseconds.

5.
HarperDB | Enterprise Application Platform
https://www.harperd
.io/

HarperDB's global application platform simplifies development with one package that includes a lightning-fast database, embedded API server, and real-time global data replication. Deploy from cloud to edge to on-prem.

7.
eXtremeDB Database Management System for Professional Developers - McObject LLC
https://www.mcobjec
.com/

Small, fast, reliable database management system Persistent and/or in-memory data storage for edge-cloud, powerful for professional developers

9.
The Snowflake AI Data Cloud - Mobilize Data, Apps, and AI
https://www.snowflak
.com/

Snowflake enables organizations to learn, build, and connect with their data-driven peers. Collaborate, build data apps & power diverse workloads in the AI Data Cloud.